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Effect of a Probiotic Supplement on Insulin Sensitivity and Skeletal Muscle Substrate Oxidation during High Fat Feeding- [electronic resource]
Effect of a Probiotic Supplement on Insulin Sensitivity and Skeletal Muscle Substrate Oxidation during High Fat Feeding- [electronic resource]
상세정보
- 자료유형
- 학위논문(국외)
- 자관 청구기호
- 기본표목-개인명
- 표제와 책임표시사항
- Effect of a Probiotic Supplement on Insulin Sensitivity and Skeletal Muscle Substrate Oxidation during High Fat Feeding - [electronic resource] / Osterberg, Kristin Linnea.
- 발행, 배포, 간사 사항
- 발행, 배포, 간사 사항
- 형태사항
- 1 online resource(110 p)
- 일반주기
- Source: Dissertation Abstracts International, Volume: 79-01(E), Section: B.
- 일반주기
- Adviser: Kevin P. Davy.
- 학위논문주기
- Thesis (Ph.D.)--Virginia Polytechnic Institute and State University, 2014.
- 이용제한주기
- This item is not available from ProQuest Dissertations & Theses.
- 요약 등 주기
- 요약Background: Modifying the gut microbiota through the administration of probiotics during high fat feeding has been shown to attenuate weight gain and body fat accretion while improving insulin sensitivity in animal models.
- 요약 등 주기
- 요약Objective: Our objective was to determine the effects of the probiotic VSL#3 on body weightand composition, skeletal muscle substrate oxidation, and insulin sensitivity and during 4 weeks of high-fat, hypercaloric feeding. We hypothesized that the probiotic would attenuate the body weight and fat gain and adverse changes in insulin sensitivity and substrate oxidation following high fat, hypercaloric feeding in young, non-obese males.
- 요약 등 주기
- 요약Methods: Twenty non-obese males (18-30 y) volunteered to participate in the present study. Following a 2-week eucaloric control diet, subjects underwent a dual x-ray absorptiometry (DXA) to determine body composition, an intravenous glucose tolerance test (IVGTT) to determine insulin sensitivity, a skeletal muscle biopsy for measurement of substrate oxidation. Serum endotoxin was also measured. Subsequently, subjects were randomized to receive either VSL#3 (2 satchets) or placebo during 4 weeks of consuming a high fat (55% fat), hypercaloric diet (+1,000 kcal/day). Macronutrient composition of the high fat diet was 55% fat, 30% carbohydrate, and 15% protein.
- 요약 등 주기
- 요약Results: There were no differences between the groups in subject characteristics or in the dependent variables at baseline. Body weight and fat mass increased less (P0.045) following the high fat diet with VSL#3 compared to placebo. Insulin sensitivity (and other IVGTT variables) and both glucose and fat oxidation did not change significantly with time or VSL#3 treatment. Serum endotoxin concentration was not different between groups following the high-fat diet.
- 요약 등 주기
- 요약Conclusions: VSL#3, a multi-strain probiotic, attenuated body weight and fat gain following a 4- week high fat, hypercaloric diet compared with a placebo. There were no differences between the VSL and control in circulating endotoxin, insulin sensitivity (and other IVGTT variables) or in skeletal muscle substrate oxidation.
- 주제명부출표목-일반주제명
- 부출표목-단체명
- 기본자료저록
- Dissertation Abstracts International. 79-01B(E).
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 원문정보보기
- 소장사항
-
20180515 2018
MARC
008180601s2014 us esm 001c eng■001MOKWON01257818
■00520180518094411
■007cr
■020 ▼a9780355210804
■035 ▼a(MiAaPQ)AAI10647608
■040 ▼aMiAaPQ▼cMiAaPQ
■090 ▼a전자도서(박사논문)
■1001 ▼aOsterberg, Kristin Linnea.
■24510▼aEffect of a Probiotic Supplement on Insulin Sensitivity and Skeletal Muscle Substrate Oxidation during High Fat Feeding▼h[electronic resource]▼cOsterberg, Kristin Linnea.
■260 ▼a[Sl]▼bVirginia Polytechnic Institute and State University▼c2014
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2014
■300 ▼a1 online resource(110 p)
■500 ▼aSource: Dissertation Abstracts International, Volume: 79-01(E), Section: B.
■500 ▼aAdviser: Kevin P. Davy.
■5021 ▼aThesis (Ph.D.)--Virginia Polytechnic Institute and State University, 2014.
■506 ▼aThis item is not available from ProQuest Dissertations & Theses.
■520 ▼aBackground: Modifying the gut microbiota through the administration of probiotics during high fat feeding has been shown to attenuate weight gain and body fat accretion while improving insulin sensitivity in animal models.
■520 ▼aObjective: Our objective was to determine the effects of the probiotic VSL#3 on body weightand composition, skeletal muscle substrate oxidation, and insulin sensitivity and during 4 weeks of high-fat, hypercaloric feeding. We hypothesized that the probiotic would attenuate the body weight and fat gain and adverse changes in insulin sensitivity and substrate oxidation following high fat, hypercaloric feeding in young, non-obese males.
■520 ▼aMethods: Twenty non-obese males (18-30 y) volunteered to participate in the present study. Following a 2-week eucaloric control diet, subjects underwent a dual x-ray absorptiometry (DXA) to determine body composition, an intravenous glucose tolerance test (IVGTT) to determine insulin sensitivity, a skeletal muscle biopsy for measurement of substrate oxidation. Serum endotoxin was also measured. Subsequently, subjects were randomized to receive either VSL#3 (2 satchets) or placebo during 4 weeks of consuming a high fat (55% fat), hypercaloric diet (+1,000 kcal/day). Macronutrient composition of the high fat diet was 55% fat, 30% carbohydrate, and 15% protein.
■520 ▼aResults: There were no differences between the groups in subject characteristics or in the dependent variables at baseline. Body weight and fat mass increased less (P0.045) following the high fat diet with VSL#3 compared to placebo. Insulin sensitivity (and other IVGTT variables) and both glucose and fat oxidation did not change significantly with time or VSL#3 treatment. Serum endotoxin concentration was not different between groups following the high-fat diet.
■520 ▼aConclusions: VSL#3, a multi-strain probiotic, attenuated body weight and fat gain following a 4- week high fat, hypercaloric diet compared with a placebo. There were no differences between the VSL and control in circulating endotoxin, insulin sensitivity (and other IVGTT variables) or in skeletal muscle substrate oxidation.
■590 ▼aSchool code: 0247.
■650 4▼aNutrition
■690 ▼a0570
■71020▼aVirginia Polytechnic Institute and State University▼bHuman Nutrition, Foods and Exercise.
■7730 ▼tDissertation Abstracts International▼g79-01B(E).
■773 ▼tDissertation Abstract International
■790 ▼a0247
■791 ▼aPh.D.
■792 ▼a2014
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T14823901▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a20180515▼f2018
