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Gut Microbiota and Systemic Autoimmunity: Ameliorating Systemic Lupus Erythematosus through Diet, Microbiota, and Host Immune System Interactions.- [electronic resource] : Zegarra Ruiz, Daniel Fernando.
Gut Microbiota and Systemic Autoimmunity: Ameliorating Systemic Lupus Erythematosus through Diet, Microbiota, and Host Immune System Interactions.- [electronic resource] : Zegarra Ruiz, Daniel Fernando.
상세정보
- 자료유형
- 학위논문(국외)
- 청구기호
- 저자명
- 서명/저자
- Gut Microbiota and Systemic Autoimmunity: Ameliorating Systemic Lupus Erythematosus through Diet, Microbiota, and Host Immune System Interactions. - [electronic resource] : Zegarra Ruiz, Daniel Fernando.
- 발행사항
- 발행사항
- 형태사항
- 1 online resource(184 p.)
- 주기사항
- Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
- 주기사항
- Adviser: Martin Alexander Kriegel.
- 학위논문주기
- Thesis (Ph.D.)--Yale University, 2018.
- 초록/해제
- 요약Autoimmune diseases are a major health problem affecting over 200 million people worldwide and represent one of the leading causes of death for women under 65 years old. Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that
- 초록/해제
- 요약Alterations in the gut microbiota composition have been associated to autoimmune diseases, but it is largely unknown which specific bacterial communities are responsible for these effects. Interestingly, diet has been demonstrated to shape the g
- 초록/해제
- 요약I utilized a spontaneous and inducible lupus model to dissect the role that diet, gut microbiota, and their interactions play in SLE. For the spontaneous model, I worked with toll-like receptor 7 transgenic (TLR7.1 Tg) mice that develop SLE-like
- 초록/해제
- 요약In chapter II, I demonstrate the role that gut microbiota plays on SLE. Fecal 16S rDNA sequencing was performed and I identified that murine SLE models developed intestinal dysbiosis. Depletion of the gut microbiota reduced mortality and pathoge
- 초록/해제
- 요약In chapter III, I identify a key bacterial strain that exacerbates SLE. Through culture of internal organs I revealed that L. reuteri (LR) translocated outside the gut in SLE-prone mice and in cohoused wild type littermates. In addition, 16S rDN
- 초록/해제
- 요약Finally, in chapter IV, I fed a RS enriched diet to our lupus mouse models before onset of disease to assess if diet can ameliorate systemic autoimmunity through modulation of the gut microbiome and LR outgrowth inhibition. Fecal 16S rDNA sequen
- 초록/해제
- 요약In conclusion, the research outline in this thesis contributes to a better understanding of the effects of RS on lupus pathogenesis through modulation of the gut microbiome and suppression of pathobionts, representing a safer approach to amelior
- 일반주제명
- 일반주제명
- 일반주제명
- 기타저자
- 기본자료저록
- Dissertation Abstracts International. 79-12B(E).
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 원문정보보기
- 소장사항
-
201812 2019
MARC
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■040 ▼aMiAaPQ▼cMiAaPQ
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■090 ▼a전자도서(박사논문)
■1001 ▼aZegarra Ruiz, Daniel Fernando.
■24510▼aGut Microbiota and Systemic Autoimmunity: Ameliorating Systemic Lupus Erythematosus through Diet, Microbiota, and Host Immune System Interactions.▼h[electronic resource]▼cZegarra Ruiz, Daniel Fernando.
■260 ▼a[S.l.]▼bYale University. ▼c2018
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2018
■300 ▼a1 online resource(184 p.)
■500 ▼aSource: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
■500 ▼aAdviser: Martin Alexander Kriegel.
■5021 ▼aThesis (Ph.D.)--Yale University, 2018.
■520 ▼aAutoimmune diseases are a major health problem affecting over 200 million people worldwide and represent one of the leading causes of death for women under 65 years old. Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that
■520 ▼aAlterations in the gut microbiota composition have been associated to autoimmune diseases, but it is largely unknown which specific bacterial communities are responsible for these effects. Interestingly, diet has been demonstrated to shape the g
■520 ▼aI utilized a spontaneous and inducible lupus model to dissect the role that diet, gut microbiota, and their interactions play in SLE. For the spontaneous model, I worked with toll-like receptor 7 transgenic (TLR7.1 Tg) mice that develop SLE-like
■520 ▼aIn chapter II, I demonstrate the role that gut microbiota plays on SLE. Fecal 16S rDNA sequencing was performed and I identified that murine SLE models developed intestinal dysbiosis. Depletion of the gut microbiota reduced mortality and pathoge
■520 ▼aIn chapter III, I identify a key bacterial strain that exacerbates SLE. Through culture of internal organs I revealed that L. reuteri (LR) translocated outside the gut in SLE-prone mice and in cohoused wild type littermates. In addition, 16S rDN
■520 ▼aFinally, in chapter IV, I fed a RS enriched diet to our lupus mouse models before onset of disease to assess if diet can ameliorate systemic autoimmunity through modulation of the gut microbiome and LR outgrowth inhibition. Fecal 16S rDNA sequen
■520 ▼aIn conclusion, the research outline in this thesis contributes to a better understanding of the effects of RS on lupus pathogenesis through modulation of the gut microbiome and suppression of pathobionts, representing a safer approach to amelior
■590 ▼aSchool code: 0265.
■650 4▼aImmunology.
■650 4▼aHealth sciences.
■650 4▼aMicrobiology.
■690 ▼a0982
■690 ▼a0566
■690 ▼a0410
■71020▼aYale University.
■7730 ▼tDissertation Abstracts International▼g79-12B(E).
■773 ▼tDissertation Abstract International
■790 ▼a0265
■791 ▼aPh.D.
■792 ▼a2018
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T15001245▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a201812▼f2019
