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Molecular Pathways Underlying Cerebellar Abiotrophy in Arabian Horses.- [electronic resource] : Scott, Erica Yuki Azetsu.
Molecular Pathways Underlying Cerebellar Abiotrophy in Arabian Horses. - [electronic resou...
Molecular Pathways Underlying Cerebellar Abiotrophy in Arabian Horses.- [electronic resource] : Scott, Erica Yuki Azetsu.

상세정보

자료유형  
 학위논문(국외)
청구기호  
저자명  
서명/저자  
Molecular Pathways Underlying Cerebellar Abiotrophy in Arabian Horses. - [electronic resource] : Scott, Erica Yuki Azetsu.
발행사항  
발행사항  
Ann Arbor : ProQuest Dissertations & Theses , 2017
    형태사항  
    1 online resource(158 p.)
    주기사항  
    Source: Dissertation Abstracts International, Volume: 79-08(E), Section: B.
    주기사항  
    Advisers: James D. Murray
    학위논문주기  
    Thesis (Ph.D.)--University of California, Davis, 2017.
    사용제한주기  
    This item is not available from ProQuest Dissertations & Theses.
    초록/해제  
    요약Cerebellar Abiotrophy is a neurodegenerative disease with an inherited component, resulting in neurodegeneration in the cerebellum. Cerebellar abiotrophy (CA) affects Arabian horses and results in an ataxic phenotype involving uncoordinated limb
    초록/해제  
    요약The uncertainty revolving around the ramifications of the CA-associated SNP on the candidate genes and crucial pathways in the cerebellum drove us to investigate the transcriptome-wide differences between healthy and CA-affected horses. Pathways
    초록/해제  
    요약Total RNA sequencing (RNA-seq) suggested differential MUTYH isoform usage in CA-affected horses. We confirmed this using more targeted approaches of quantifying mRNA expression and uncovered differential MUTYH promoter usage as well as MUTYH pro
    일반주제명  
    일반주제명  
    일반주제명  
    기타저자  
    기본자료저록  
    Dissertation Abstracts International. 79-08B(E).
    기본자료저록  
    Dissertation Abstract International
    전자적 위치 및 접속  
     원문정보보기
    소장사항  
    201812 2019

    MARC

     008190529s2017        ulk          s          00        eng
    ■001000014996670
    ■00520190102171228
    ■007cr
    ■020    ▼a9780355763287
    ■035    ▼a(MiAaPQ)AAI10635842
    ■035    ▼a(MiAaPQ)ucdavis:17402
    ■040    ▼aMiAaPQ▼cMiAaPQ
    ■08204▼a636
    ■090    ▼a전자도서(박사논문)
    ■1001  ▼aScott,  Erica  Yuki  Azetsu.
    ■24510▼aMolecular  Pathways  Underlying  Cerebellar  Abiotrophy  in  Arabian  Horses.▼h[electronic  resource]▼cScott,  Erica  Yuki  Azetsu.
    ■260    ▼a[S.l.]▼bUniversity  of  California,  Davis.  ▼c2017
    ■260  1▼aAnn  Arbor▼bProQuest  Dissertations  &  Theses▼c2017
    ■300    ▼a1  online  resource(158  p.)
    ■500    ▼aSource:  Dissertation  Abstracts  International,  Volume:  79-08(E),  Section:  B.
    ■500    ▼aAdvisers:  James  D.  Murray
    ■5021  ▼aThesis  (Ph.D.)--University  of  California,  Davis,  2017.
    ■506    ▼aThis  item  is  not  available  from  ProQuest  Dissertations  &  Theses.
    ■520    ▼aCerebellar  Abiotrophy  is  a  neurodegenerative  disease  with  an  inherited  component,  resulting  in  neurodegeneration  in  the  cerebellum.  Cerebellar  abiotrophy  (CA)  affects  Arabian  horses  and  results  in  an  ataxic  phenotype  involving  uncoordinated  limb
    ■520    ▼aThe  uncertainty  revolving  around  the  ramifications  of  the  CA-associated  SNP  on  the  candidate  genes  and  crucial  pathways  in  the  cerebellum  drove  us  to  investigate  the  transcriptome-wide  differences  between  healthy  and  CA-affected  horses.  Pathways
    ■520    ▼aTotal  RNA  sequencing  (RNA-seq)  suggested  differential  MUTYH  isoform  usage  in  CA-affected  horses.  We  confirmed  this  using  more  targeted  approaches  of  quantifying  mRNA  expression  and  uncovered  differential  MUTYH  promoter  usage  as  well  as  MUTYH  pro
    ■590    ▼aSchool  code:  0029.
    ■650  4▼aAnimal  sciences.
    ■650  4▼aAnimal  diseases.
    ■650  4▼aNeurosciences.
    ■690    ▼a0475
    ■690    ▼a0476
    ■690    ▼a0317
    ■71020▼aUniversity  of  California,  Davis▼bAnimal  Biology.
    ■7730  ▼tDissertation  Abstracts  International▼g79-08B(E).
    ■773    ▼tDissertation  Abstract  International
    ■790    ▼a0029
    ■791    ▼aPh.D.
    ■792    ▼a2017
    ■793    ▼aEnglish
    ■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T14996670▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.
    ■980    ▼a201812▼f2019

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