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The Role of Host Inflammation and the Commensal Microbiota in the Pathogenesis of Medication-related Osteonecrosis of the Jaw.- [electronic resource]
The Role of Host Inflammation and the Commensal Microbiota in the Pathogenesis of Medication-related Osteonecrosis of the Jaw.- [electronic resource]
상세정보
- 자료유형
- 학위논문(국외)
- 자관 청구기호
- 기본표목-개인명
- 표제와 책임표시사항
- The Role of Host Inflammation and the Commensal Microbiota in the Pathogenesis of Medication-related Osteonecrosis of the Jaw. - [electronic resource] / Williams, Drake Winslow.
- 발행, 배포, 간사 사항
- 발행, 배포, 간사 사항
- 형태사항
- 1 online resource(100 p.)
- 일반주기
- Source: Dissertations Abstracts International, Volume: 80-12, Section: B.
- 일반주기
- Publisher info.: Dissertation/Thesis.
- 일반주기
- Advisor: Kim, Reuben H.
- 학위논문주기
- Thesis (Ph.D.)--University of California, Los Angeles, 2019.
- 이용제한주기
- This item must not be sold to any third party vendors.
- 요약 등 주기
- 요약Bisphosphonates (BPs) and denosumab (Dmab) are anti-resorptive drugs that are clinically used to treat bone disorders like osteoporosis and bone metastases. A detrimental side effect of these drugs that uniquely occurs in the oral cavity is BP- and Dmab-related osteonecrosis of the jaw (collectively called medication-related osteonecrosis of the jaw, or MRONJ), clinically defined as exposed necrotic bone with unclosed overlaying oral mucosa for at least 8 weeks. Although the first report of ONJ by BPs appeared in 2003, the exact pathophysiology of MRONJ is still largely unknown. Our laboratory has been working to examine and elucidate the pathophysiology of MRONJ. Previously, we established mouse models for MRONJ utilizing bisphosphonate and 慣RANKL antibody and identified that woven bone formation and inhibition of bone resorption are hallmarks of murine MRONJ lesions. We also utilized semi-unbiased gene profiling to identify and validate the importance of IL36 signaling in MRONJ pathogenesis.MRONJ often occurs following a dental intervention such as a tooth extraction which is typically performed to eliminate localized periodontal or periapical inflammation. Periodontal disease is caused by polymicrobial infection and subsequent host immune response
- 주제명부출표목-일반주제명
- 부출표목-단체명
- 기본자료저록
- Dissertations Abstracts International. 80-12B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 원문정보보기
MARC
008200317s2019 ulk s 00 eng■001000015491765
■00520200217181411
■007cr
■020 ▼a9781392233672
■040 ▼d225006
■08204▼a617.6
■090 ▼a전자도서(박사논문)
■1001 ▼aWilliams, Drake Winslow.
■24514▼aThe Role of Host Inflammation and the Commensal Microbiota in the Pathogenesis of Medication-related Osteonecrosis of the Jaw.▼h[electronic resource]▼cWilliams, Drake Winslow.
■260 ▼a[S.l.]▼bUniversity of California, Los Angeles. ▼c2019
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2019
■300 ▼a1 online resource(100 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 80-12, Section: B.
■500 ▼aPublisher info.: Dissertation/Thesis.
■500 ▼aAdvisor: Kim, Reuben H.
■5021 ▼aThesis (Ph.D.)--University of California, Los Angeles, 2019.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aBisphosphonates (BPs) and denosumab (Dmab) are anti-resorptive drugs that are clinically used to treat bone disorders like osteoporosis and bone metastases. A detrimental side effect of these drugs that uniquely occurs in the oral cavity is BP- and Dmab-related osteonecrosis of the jaw (collectively called medication-related osteonecrosis of the jaw, or MRONJ), clinically defined as exposed necrotic bone with unclosed overlaying oral mucosa for at least 8 weeks. Although the first report of ONJ by BPs appeared in 2003, the exact pathophysiology of MRONJ is still largely unknown. Our laboratory has been working to examine and elucidate the pathophysiology of MRONJ. Previously, we established mouse models for MRONJ utilizing bisphosphonate and 慣RANKL antibody and identified that woven bone formation and inhibition of bone resorption are hallmarks of murine MRONJ lesions. We also utilized semi-unbiased gene profiling to identify and validate the importance of IL36 signaling in MRONJ pathogenesis.MRONJ often occurs following a dental intervention such as a tooth extraction which is typically performed to eliminate localized periodontal or periapical inflammation. Periodontal disease is caused by polymicrobial infection and subsequent host immune response
■650 4▼aDentistry.
■71020▼aUniversity of California, Los Angeles▼bOral Biology 0615.
■7730 ▼tDissertations Abstracts International▼g80-12B.
■773 ▼tDissertation Abstract International
■791 ▼aPh.D.
■792 ▼a2019
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T15491765▼nKERIS
