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Development of Zinc Status Biomarkers: The Role of Food in Zinc Nutrition, Intestinal Health, and Gut Microbiota- [electronic resource]
Development of Zinc Status Biomarkers: The Role of Food in Zinc Nutrition, Intestinal Health, and Gut Microbiota- [electronic resource]
상세정보
- 자료유형
- 학위논문(국외)
- 자관 청구기호
- 기본표목-개인명
- 표제와 책임표시사항
- Development of Zinc Status Biomarkers: The Role of Food in Zinc Nutrition, Intestinal Health, and Gut Microbiota - [electronic resource] / Jacquelyn Cheng
- 발행, 배포, 간사 사항
- 발행, 배포, 간사 사항
- 형태사항
- 1 online resource(p.285 )
- 일반주기
- Source: Dissertations Abstracts International, Volume: 84-12, Section: B.
- 일반주기
- Advisor: Tako, Elad.
- 학위논문주기
- Thesis (Ph.D.)--Cornell University, 2023.
- 이용제한주기
- This item must not be sold to any third party vendors.
- 요약 등 주기
- 요약Zinc deficiency is predicted to affect over 1 billion (17%) of the world's population, including 12% of the U.S. population. Over 3000 human proteins bind zinc, where zinc plays vital biochemical and structural roles in cellular and organ function. Widely utilized biomarkers of zinc nutritional status lack sensitivity and specificity to assess zinc intervention impact due to the ubiquitous nature of zinc in human biological systems. Biofortification to deliver increased bioavailable zinc through staple crops, either through increasing zinc or crop-derived bioactive content, or a combination thereof, represents a promising strategy to complement existing zinc intervention efforts. This dissertation presents the utilization of a panel of predictive indices to assess zinc status reliably and accurately and further investigates the utility of novel zinc status biomarkers. The role of biofortified staple crops and food ingredients in altering intestinal functionality and the gut microbiome as it relates to intestinal zinc absorption and status is also presented. Chapter 1 summarizes zinc essentiality in human health, intestinal zinc absorption, zinc biomarkers, and zinc deficiency alleviation strategies. Chapter 2 systematically reviews literature on gut microbiome composition and function as it relates to dietary zinc and zinc status and assesses the applicability of the gut microbiome as a potential zinc status biomarker. Chapter 3 evaluates potential negative implications associated with food additive nanoparticle consumption on intestinal functionality and morphology in vivo and thus essential nutrient (zinc) absorption and bioavailability. Chapter 4 examines the beneficial and nutritional effects of genistein (plant-origin bioactive) in potentially improving mineral (zinc) dietary bioavailability, intestinal functionality, morphology, and altering gut microbiome composition in vivo. Chapter 5 focuses on understanding nicotianamine (mineral transporter naturally present in plants) enhancement as a potential strategy for zinc biofortification via in vivo screening of three varieties of nicotianamine-biofortified wheat on improving mineral (zinc) bioavailability and intestinal functionality and morphology. Chapter 6 focuses on development and validation of the Zinc Status Index concept, a statistical model based on a panel of biochemical markers reactive to dietary zinc manipulation. To conclude, Chapter 7 highlights significant findings in Chapters 2-6 and suggests future work for each.
- 주제명부출표목-일반주제명
- 주제명부출표목-일반주제명
- 주제명부출표목-일반주제명
- 비통제 색인어
- 비통제 색인어
- 비통제 색인어
- 비통제 색인어
- 비통제 색인어
- 비통제 색인어
- 부출표목-단체명
- 기본자료저록
- Dissertations Abstracts International. 84-12B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 원문정보보기
- 소장사항
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202402 2024
MARC
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■040 ▼aMiAaPQ▼cMiAaPQ
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■090 ▼a전자도서(박사논문)
■1001 ▼aCheng, Jacquelyn.▼0(orcid)0000-0002-1293-413X
■24510▼aDevelopment of Zinc Status Biomarkers: The Role of Food in Zinc Nutrition, Intestinal Health, and Gut Microbiota▼h[electronic resource]▼cJacquelyn Cheng
■260 ▼a[S.l.]▼bCornell University. ▼c2023
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2023
■300 ▼a1 online resource(p.285 )
■500 ▼aSource: Dissertations Abstracts International, Volume: 84-12, Section: B.
■500 ▼aAdvisor: Tako, Elad.
■5021 ▼aThesis (Ph.D.)--Cornell University, 2023.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aZinc deficiency is predicted to affect over 1 billion (17%) of the world's population, including 12% of the U.S. population. Over 3000 human proteins bind zinc, where zinc plays vital biochemical and structural roles in cellular and organ function. Widely utilized biomarkers of zinc nutritional status lack sensitivity and specificity to assess zinc intervention impact due to the ubiquitous nature of zinc in human biological systems. Biofortification to deliver increased bioavailable zinc through staple crops, either through increasing zinc or crop-derived bioactive content, or a combination thereof, represents a promising strategy to complement existing zinc intervention efforts. This dissertation presents the utilization of a panel of predictive indices to assess zinc status reliably and accurately and further investigates the utility of novel zinc status biomarkers. The role of biofortified staple crops and food ingredients in altering intestinal functionality and the gut microbiome as it relates to intestinal zinc absorption and status is also presented. Chapter 1 summarizes zinc essentiality in human health, intestinal zinc absorption, zinc biomarkers, and zinc deficiency alleviation strategies. Chapter 2 systematically reviews literature on gut microbiome composition and function as it relates to dietary zinc and zinc status and assesses the applicability of the gut microbiome as a potential zinc status biomarker. Chapter 3 evaluates potential negative implications associated with food additive nanoparticle consumption on intestinal functionality and morphology in vivo and thus essential nutrient (zinc) absorption and bioavailability. Chapter 4 examines the beneficial and nutritional effects of genistein (plant-origin bioactive) in potentially improving mineral (zinc) dietary bioavailability, intestinal functionality, morphology, and altering gut microbiome composition in vivo. Chapter 5 focuses on understanding nicotianamine (mineral transporter naturally present in plants) enhancement as a potential strategy for zinc biofortification via in vivo screening of three varieties of nicotianamine-biofortified wheat on improving mineral (zinc) bioavailability and intestinal functionality and morphology. Chapter 6 focuses on development and validation of the Zinc Status Index concept, a statistical model based on a panel of biochemical markers reactive to dietary zinc manipulation. To conclude, Chapter 7 highlights significant findings in Chapters 2-6 and suggests future work for each.
■590 ▼aSchool code: 0058.
■650 4▼aFood science.
■650 4▼aNutrition.
■650 4▼aBiochemistry.
■653 ▼aBiofortification
■653 ▼aBiomarker
■653 ▼aGut health
■653 ▼aMicrobiome
■653 ▼aZinc transporter
■653 ▼aMorphology
■690 ▼a0359
■690 ▼a0570
■690 ▼a0487
■71020▼aCornell University▼bFood Science and Technology.
■7730 ▼tDissertations Abstracts International▼g84-12B.
■773 ▼tDissertation Abstract International
■790 ▼a0058
■791 ▼aPh.D.
■792 ▼a2023
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16931614▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
