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the synthesis of 2'-deoxythymidine derivatives and the cycloaddition route to 2'-deoxy-o-glycosidic linkages (thiothymadine). [microform]
the synthesis of 2'-deoxythymidine derivatives and the cycloaddition route to 2'-deoxy-o-glycosidic linkages (thiothymadine). [microform]
상세정보
- 자료유형
- 마이크로피시
- 청구기호
- 저자명
- 서명/저자
- the synthesis of 2-deoxythymidine derivatives and the cycloaddition route to 2-deoxy-o-glycosidic linkages (thiothymadine). - [microform]
- 발행사항
- 형태사항
- 244 p. : microfiches ; 11×15 cm.
- 총서명
- UMI Dissertation
- 주기사항
- Source: Dissertation Abstracts International, Volume: 58-01, Section: B, page: 0203.
- 학위논문주기
- thesis (ph.d.)-- - city university of new york, 1997.
- 초록/해제
- 요약Part 1. The synthesis of 2$\sp\prime$-deoxy-2$\sp\prime$-thiothymidine derivatives was accomplished by utilizing both tolyl(bistolylthio)sulfonium salt and dimethyl(methylthio)sulfonium salt as the electrophilic reagent in the glycosyl transfer of ribal derivatives and bis-silylated thymine. The effect of the size of the C-3 blocking group, the temperature of the reaction, and the polarity of solvent on the facial selectivity of the sulfonium species was investigated.
- 초록/해제
- 요약Part 2. A novel method for the construction of the 2$\sp\prime$-deoxy-O-glycosidic linkage was developed. Our approach involved an inverse electron demand Diels-Alder reaction between sugar dienophiles and a thione diene. The facial selectivity of the cycloaddition was dependent on the stereochemistry of the substituents of the glycals and on the choice of solvent. The below facial cycloadduct, upon exposure to Raney Nickel provided the 2-deoxy-O-$\alpha$-disaccharide.
- 복제주기
- Microfiche : UMI . microfiches;11×15 cm.
- 일반주제명
- 키워드
- 기타저자
- 기본자료저록
- Dissertation Abstracts International. 58-01B.
MARC
008970923s1997 us eng■001MOKWON00235035
■001AAV9720092
■00519981007111623
■008970923s1997 us eng
■035 ▼a(UnM)AAV9720092
■040 ▼aUnM▼cUnM▼dMOKWON
■090 ▼a540▼bG298s
■1001 ▼ageer, aloma b.
■24510▼athe synthesis of 2'-deoxythymidine derivatives and the cycloaddition route to 2'-deoxy-o-glycosidic linkages (thiothymadine).▼h[microform]
■260 ▼aU.S.▼bcity university of new york▼c1997.
■300 ▼a244 p.▼bmicrofiches▼c11×15 cm.
■350 ▼a$50.6
■44000▼aUMI Dissertation
■500 ▼aSource: Dissertation Abstracts International, Volume: 58-01, Section: B, page: 0203.
■502 ▼athesis (ph.d.)--▼bcity university of new york▼d1997.
■520 ▼aPart 1. The synthesis of 2$\sp\prime$-deoxy-2$\sp\prime$-thiothymidine derivatives was accomplished by utilizing both tolyl(bistolylthio)sulfonium salt and dimethyl(methylthio)sulfonium salt as the electrophilic reagent in the glycosyl transfer of ribal derivatives and bis-silylated thymine. The effect of the size of the C-3 blocking group, the temperature of the reaction, and the polarity of solvent on the facial selectivity of the sulfonium species was investigated.
■520 ▼aPart 2. A novel method for the construction of the 2$\sp\prime$-deoxy-O-glycosidic linkage was developed. Our approach involved an inverse electron demand Diels-Alder reaction between sugar dienophiles and a thione diene. The facial selectivity of the cycloaddition was dependent on the stereochemistry of the substituents of the glycals and on the choice of solvent. The below facial cycloadduct, upon exposure to Raney Nickel provided the 2-deoxy-O-$\alpha$-disaccharide.
■533 ▼aMicrofiche▼cUMI▼emicrofiches;11×15 cm.
■590 ▼aSchool code: 0046.
■650 4▼aChemistry, Organic
■653 ▼athe▼asynthesis▼aof▼a2'-deoxythymidine▼aderivatives▼aand▼athe▼acycloaddition▼aroute▼ato▼a2'-deoxy-o-glycosidic▼alinkages▼a(thiothymadine).
■690 ▼a0490
■71020▼acity university of new york.
■7730 ▼tDissertation Abstracts International▼g58-01B.
■790 ▼a0046
■791 ▼aPH.D.
■792 ▼a1997
