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synthesis of the polyene macrolide antibiotic roflamycoin and 17-deoxyroflamycoin, and, synthetic studies toward dodecahedrane. [microform]
synthesis of the polyene macrolide antibiotic roflamycoin and 17-deoxyroflamycoin, and, synthetic studies toward dodecahedrane. [microform]
상세정보
- 자료유형
- 마이크로피시
- 청구기호
- 저자명
- 서명/저자
- synthesis of the polyene macrolide antibiotic roflamycoin and 17-deoxyroflamycoin, and, synthetic studies toward dodecahedrane. - [microform]
- 발행사항
- 형태사항
- 133 p. : microfiches ; 11×15 cm.
- 총서명
- UMI Dissertation
- 주기사항
- Source: Dissertation Abstracts International, Volume: 58-02, Section: B, page: 0712.
- 학위논문주기
- thesis (ph.d.)-- - university of california, irvine, 1997.
- 초록/해제
- 요약Part I. Roflamycoin is an unusual member of the polyene macrolide antibiotics as it is the only oxopolyene macrolide that has been shown to form well-defined ion channels. The complex polyol chain of roflamycoin, containing all of the stereogenic centers, has been successfully assembled using cyanohydrin acetonide alkylation chemistry, which has ultimately led to the first total synthesis of roflamycoin. The first roflamycoin analog, 17-deoxyroflamycoin has been successfully prepared using the same synthetic strategy of roflamycoin synthesis, and its bioactivity has been evaluated.
- 초록/해제
- 요약Part II. Dodecahedrane, the $\rm C\sb{20}H\sb{20}$ polyhedrane, has drawn great attention from both synthetic and mechanistic chemists. This attention stems from its unique geometry, $I\sb{\rm h}$-symmetry, the possible encapsulation of atoms in a cavity incapable of solvation, and its relevance to questions of conformation and bonding. An alternative synthetic route for dodecahedrane based on olefin metathesis chemistry has been investigated. Synthesis of the olefin metathesis precursors and the results of olefin metathesis reactions are discussed.
- 복제주기
- Microfiche : UMI . microfiches;11×15 cm.
- 일반주제명
- 일반주제명
- 키워드
- 기타저자
- 기본자료저록
- Dissertation Abstracts International. 58-02B.
MARC
008970923s1997 us eng■001MOKWON00235167
■001AAV9721423
■00519981008104539
■008970923s1997 us eng
■035 ▼a(UnM)AAV9721423
■040 ▼aUnM▼cUnM▼dMOKWON
■090 ▼a540▼bY22s
■1001 ▼ayang, guang.
■24510▼asynthesis of the polyene macrolide antibiotic roflamycoin and 17-deoxyroflamycoin, and, synthetic studies toward dodecahedrane.▼h[microform]
■260 ▼aU.S.▼buniversity of california▼cirvine,
■300 ▼a133 p.▼bmicrofiches▼c11×15 cm.
■350 ▼a$50.6
■44000▼aUMI Dissertation
■500 ▼aSource: Dissertation Abstracts International, Volume: 58-02, Section: B, page: 0712.
■502 ▼athesis (ph.d.)--▼buniversity of california▼dirvine▼d1997.
■520 ▼aPart I. Roflamycoin is an unusual member of the polyene macrolide antibiotics as it is the only oxopolyene macrolide that has been shown to form well-defined ion channels. The complex polyol chain of roflamycoin, containing all of the stereogenic centers, has been successfully assembled using cyanohydrin acetonide alkylation chemistry, which has ultimately led to the first total synthesis of roflamycoin. The first roflamycoin analog, 17-deoxyroflamycoin has been successfully prepared using the same synthetic strategy of roflamycoin synthesis, and its bioactivity has been evaluated.
■520 ▼aPart II. Dodecahedrane, the $\rm C\sb{20}H\sb{20}$ polyhedrane, has drawn great attention from both synthetic and mechanistic chemists. This attention stems from its unique geometry, $I\sb{\rm h}$-symmetry, the possible encapsulation of atoms in a cavity incapable of solvation, and its relevance to questions of conformation and bonding. An alternative synthetic route for dodecahedrane based on olefin metathesis chemistry has been investigated. Synthesis of the olefin metathesis precursors and the results of olefin metathesis reactions are discussed.
■533 ▼aMicrofiche▼cUMI▼emicrofiches;11×15 cm.
■590 ▼aSchool code: 0030.
■650 4▼aChemistry, Organic
■650 4▼aChemistry, Pharmaceutical
■653 ▼asynthesis▼aof▼athe▼apolyene▼amacrolide▼aantibiotic▼aroflamycoin▼aand▼a17-deoxyroflamycoin▼aand▼asynthetic▼astudies▼atoward▼adodecahedrane.
■690 ▼a0490
■690 ▼a0491
■71020▼auniversity of california, irvine.
■7730 ▼tDissertation Abstracts International▼g58-02B.
■790 ▼a0030
■791 ▼aPH.D.
■792 ▼a1997
